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HLA-haploidentical stem cell transplantation for chronic granulomatous disease: an EBMT-IEWP retrospective study.
Blood
March 2025
Hospital Necker-Enfants Malades, Assistance Publique-Hospitaux de Paris, INSERM, paris, France.
Chronic granulomatous disease (CGD) is an inborn error of immunity characterized by defective NADPH oxidase function, leading to impaired microbial killing, recurrent infections and granulomatous inflammation. Allogenic hematopoietic stem cell transplantation (HSCT) is a curative treatment for CGD, particularly effective when a fully HLA-matched donor is available. However, the place of HLA-haploidentical HSCT remains less established.
View Article and Find Full Text PDFSNet: Self-adaptive weighted fusion and self-adaptive aligned network for multi-modal MRI segmentation.
Med Phys
March 2025
Academy of Medical Engineering and Translational Medicine, Tianjin University, Tianjin, China.
Background: Accurate segmentation of lesions is beneficial for quantitative analysis and precision medicine in multimodal magnetic resonance imaging (MRI).
Purpose: Currently, multimodal MRI fusion segmentation networks still face two main issues. On one hand, simple feature concatenation fails to fully capture the complex relationships between different modalities, as it overlooks the importance of dynamically changing feature weights across modalities.
Fully automatic categorical analysis of striatal subregions in dopamine transporter SPECT using a convolutional neural network.
Ann Nucl Med
March 2025
Department of Diagnostic and Interventional Radiology and Nuclear Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Objective: To provide fully automatic scanner-independent 5-level categorization of the [I]FP-CIT uptake in striatal subregions in dopamine transporter SPECT.
Methods: A total of 3500 [I]FP-CIT SPECT scans from two in house (n = 1740, n = 640) and two external (n = 645, n = 475) datasets were used for this study. A convolutional neural network (CNN) was trained for the categorization of the [I]FP-CIT uptake in unilateral caudate and putamen in both hemispheres according to 5 levels: normal, borderline, moderate reduction, strong reduction, almost missing.
Quantile regression under dependent censoring with unknown association.
Lifetime Data Anal
March 2025
Centre for Statistics, Data Science Institute, Hasselt University, Hasselt, Belgium.
The study of survival data often requires taking proper care of the censoring mechanism that prohibits complete observation of the data. Under right censoring, only the first occurring event is observed: either the event of interest, or a competing event like withdrawal of a subject from the study. The corresponding identifiability difficulties led many authors to imposing (conditional) independence or a fully known dependence between survival and censoring times, both of which are not always realistic.
View Article and Find Full Text PDFDecoding genetic diversity through genome engineering in bryophytes.
Plant J
March 2025
Shenzhen Branch, Guangdong Laboratory for Lingnan Modern Agriculture, Shenzhen Key Laboratory of Agricultural Synthetic Biology, Genome Analysis Laboratory of the Ministry of Agriculture and Rural Affairs, Agricultural Genomics Institute at Shenzhen, Chinese Academy of Agricultural Sciences, Shenzhen, 518124, China.
Bryophytes, which include mosses, liverworts, and hornworts, have evolved a highly successful strategy for thriving in terrestrial environments, allowing them to occupy nearly every land ecosystem. Their success is due to a unique combination of biochemical adaptations, diverse structural forms, and specialized life cycle strategies. The key to their evolutionary success lies in their genomic diversity.
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