Context: Bile rather than blood depicts the local inflammation in the liver and may improve prediction and diagnosis of acute cellular rejection (ACR) after liver transplantation (OLT).
Methods: Secretome and miRNAs were analyzed during the first two weeks and on clinical suspicion of ACR in the bile of 45 OLT recipients.
Results: Levels of CD44, CXCL9, miR-122, miR-133a, miR-148a and miR-194 were significantly higher in bile of patients who developed ACR within the first 6 months after OLT and during ACR.
Conclusion: Analysis of secretome and miRNA in bile could improve our understanding of the local inflammatory process during rejection.
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| http://dx.doi.org/10.1080/1354750X.2016.1201538 | DOI Listing |
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