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The value and significance of nucleolar organizer region proteins as markers of malignancy in breast cancer patients.
Saudi Med J
October 2024
From the Department of Clinical Laboratory Sciences (Salih, Dahlawi), College of Applied Medical Sciences, Taif University, Taif, from the Department of Medical Laboratory (Abdulgafor), King Faisal Special Hospital Research Center, Al-Madinah Al-Munawarah, and from the Department of Laboratory Medicine (Khalifa), Faculty of Applied Medical Science, University of Al Baha, Al Baha, Kingdom of Saudi Arabia.
Objectives: To assess argyrophilic nucleolar organizer regions (AgNORs) in 60 patients with primary breast carcinoma and evaluated their association with clinical prognostic parameters of breast cancer.
Methods: Argyrophilic nucleolar organizer regions were stained in paraffin sections of the tissues using Ploton's silver method. For each sample, the number of AgNORs within the nuclei of 100 tumor cells was counted.
Evaluation of the relationship between the expression of AgNOR and Ki67 with the recurrence rate in central granulomatous giant cell lesions: A case-control.
Clin Exp Dent Res
April 2024
Department of oral and maxillofacial pathology, School of Dentistry, Alborz University of Medical Science, Karaj, Iran.
Objectives: Giant cell granuloma is a local nonneoplastic lesion that is divided into two categories, based on its site of occurrence: Central and peripheral giant cell granuloma. Central giant cell granuloma is an intraosseous lesion that has a tendency to recure even in surgically treated cases. Several studies have proven that there is an association between different lesions clinical behavior and their histological features.
View Article and Find Full Text PDFFirst Cytogenetic Analysis of Gray, 1842 Provides Insights on Interspecific Chromosomal Diversification in the Genus (Squamata: Gekkonidae).
Life (Basel)
January 2024
Department of Biology, Ecology and Earth Sciences, University of Calabria, Via P. Bucci 4/B, 87036 Rende, Italy.
This contribution provides the first karyotype description of and discusses the interspecific chromosome diversification in the genus. Chromosomal analysis was performed on samples from different Malagasy populations using standard karyotyping, Ag-NOR staining, and banding methods (sequential C-banding + Giemsa, + Chromomycin A, +4',6-diamidino-2-phenylindole). Irrespective of sex or sampling locality, shows a karyotype of 2n = 42 with metacentric (1, 18-21), submetacentric (4), subtelocentric (5, 11), and acrocentric pairs (all the remaining pairs).
View Article and Find Full Text PDFCutaneous Canine Mast Cell Tumor: The Use of Proliferative Markers (Ki-67 and Ki-67 × AgNOR) in Cytological Samples for Diagnosis and Prognosis.
Vet Sci
January 2024
Laboratory of Pathology, School of Veterinary Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece.
A cytological grading system for canine mast cell tumors (MCTs) has been developed, but its integration into clinical routine has been hindered due to its diagnostic limitations. The aim of this study was to assess the prognostic value of Ki-67 and argyrophilic nucleolar organizing region (AgNOR) markers in cytological MCT samples and to determine cut-off values for these markers in correlation with histopathological grading. Cytological samples were collected prior to surgical excision, and histopathological samples were obtained postsurgery from 45 dogs diagnosed with cutaneous mast cell tumors (MCTs).
View Article and Find Full Text PDFAre Cytomorphogenetic Events Correlated with Oral Mucosal Lesions Induced by Crack Cocaine Use? A Systematic Review.
Pathophysiology
December 2023
Department of Biosciences, Institute of Health and Society, Federal University of São Paulo, Santos 11050-020, SP, Brazil.
The aim of this systematic review was to answer the question of whether crack cocaine can induce cellular and molecular alterations and whether such alterations are somehow related to clinical lesions in the oral mucosa. The searches were undertaken in three electronic databases and conducted based on the PRISMA 2020 statement. Eleven studies published between 1994 and 2020 were analyzed.
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