In order to provide high quality, cost-efficient care, it is critical to understand drivers of the cost of care. Therefore, we sought to identify clinical variables associated with high utilization (cost) in patients admitted to medical services and to develop a robust model to identify high utilization patients. In this case-control analysis, cases were identified as the 200 most costly patients admitted to internal medicine/internal medicine subspecialty services using our institution's computerized clinical data warehouse over a 7-month time period (November 1, 2012-May 31, 2013). 400 patients admitted in the same time period were randomly selected to serve as controls. The mean cost for the highest utilization patients was $126,343, while that for randomly matched patients was $15,575. In a multivariable regression model, the following variables were associated with high utilization of resources: African American race, age 35-44, admission through the emergency department, primary service of hematology-oncology, a history of heart failure or paralysis, a diagnosis of HIV, cancer, collagen vascular diseases and/or coagulopathy, a reduced albumin, and/or an elevated creatinine. The in hospital mortality rate for high utilization patients was 19%, compared to 8% for controls (p=0.0002). A predictive model using 14 different readily available clinical variables predicted high utilization with an area under the curve of 0.85. The data suggest that high utilization patients share similar demographic and clinical features. We speculate that a predictive model using commonly known patient characteristics should be able to predict high utilization patients.
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http://dx.doi.org/10.1136/jim-2016-000118 | DOI Listing |
Discov Oncol
January 2025
Department of General Surgery, The Second Affiliated Hospital of the Air Force Medical University, Xi'an, 710038, China.
A common digestive system cancer with a dismal prognosis and a high death rate globally is breast cancer (BRCA). BRCA recurrence, metastasis, and medication resistance are all significantly impacted by cancer stem cells (CSCs). However, the relationship between CSCs and the tumor microenvironment in BRCA individuals remains unknown, and this information is critically needed.
View Article and Find Full Text PDFNeuromodulation
January 2025
Department of Anesthesiology, University of Wisconsin, Madison, WI, USA.
Objectives: Past studies have shown the efficacy of spinal targeted drug delivery (TDD) in pain relief, reduction in opioid use, and cost-effectiveness in long-term management of complex chronic pain. We conducted a survey to determine treatment variables associated with patient satisfaction.
Materials And Methods: Patients in a single pain clinic who were implanted with Medtronic pain pumps to relieve intractable pain were identified from our electronic health record.
Nano Lett
January 2025
Co-Innovation Center of Efficient Processing and Utilization of Forest Resources, Nanjing Forestry University, Nanjing 210037, China.
Developing sustainable structural materials to replace traditional carbon-intensive structural materials fundamentally reshapes the concept of circular development. Herein, we propose an interface engineering strategy that utilizes water as a liquid medium to replace the residual air within natural wood. This approach minimizes the absorption of water-based softening agents by microcapillary channels of wood, enabling the controlled softening of the cell walls.
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January 2025
Department of Chemistry, University of Delhi, New Delhi, India.
Heavy metal pollution is a major environmental and health problem due to the toxicity and persistence of metals such as lead, mercury, cadmium, and arsenic in water, soil, and air. Advances in sensor technology have significantly improved the detection and quantification of heavy metals, providing real-time monitoring and mitigation tools. This review explores recent developments in heavy metal detection, focusing on innovative uses of immobilized chromogenic reagents, nanomaterials, perovskites, and nanozymes.
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January 2025
National Nanfan Research Institute, Chinese Academy of Agricultural Sciences, Sanya 572000, China; State Key Laboratory of Crop Gene Resources and Breeding/ Key laboratory Grain Crop Genetic Resources Evaluation and Utlization Ministry of Agriculture and Rural Affairs, Institute of Crop Sciences, Chinese Academy of Agricultural Sciences, Beijing 100081, China; Yazhouwan National Laboratory, Sanya 572000, China. Electronic address:
As drastic climatic changes significantly impact global agriculture, the importance of conserving and utilizing wild germplasm has gained prominance. In this context, the conservation and sustainable utilization of wild rice germplasm resources have become a high priority. Although efforts to conserve and sustainably utilize wild rice germplasm are underway globally, they are fragmented and require international cooperation to advance climate-resilient rice breeding and ensure future food securiety.
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