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Subcellular organization of UBE3A in neurons. | LitMetric

Subcellular organization of UBE3A in neurons.

J Comp Neurol

Department of Cell Biology and Physiology and Neuroscience Center, University of North Carolina, Chapel Hill, North Carolina, 27599.

Published: February 2017

AI Article Synopsis

Article Abstract

Ubiquitination regulates a broad array of cellular processes, and defective ubiquitination is implicated in several neurological disorders. Loss of the E3 ubiquitin-protein ligase UBE3A causes Angelman syndrome. Despite its clinical importance, the normal role of UBE3A in neurons is still unclear. As a step toward deciphering its possible functions, we performed high-resolution light and electron microscopic immunocytochemistry. We report a broad distribution of UBE3A in neurons, highlighted by concentrations in axon terminals and euchromatin-rich nuclear domains. Our findings suggest that UBE3A may act locally to regulate individual synapses while also mediating global, neuronwide influences through the regulation of gene transcription. J. Comp. Neurol. 525:233-251, 2017. © 2016 Wiley Periodicals, Inc.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5138109PMC
http://dx.doi.org/10.1002/cne.24063DOI Listing

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