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Influenza A(H1N1)pdm09 virus exhibiting enhanced cross-resistance to oseltamivir and peramivir due to a dual H275Y/G147R substitution, Japan, March 2016. | LitMetric
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Influenza A(H1N1)pdm09 virus exhibiting enhanced cross-resistance to oseltamivir and peramivir due to a dual H275Y/G147R substitution, Japan, March 2016.

Emi Takashita Seiichiro Fujisaki Masayuki Shirakura Kazuya Nakamura Noriko Kishida Tomoko Kuwahara Yukie Shimazu Takeshi Shimomura Shinji Watanabe Takato Odagiri

Euro Surveill

Influenza Virus Research Center, National Institute of Infectious Diseases, Tokyo, Japan.

Published: June 2016

An influenza A(H1N1)pdm09 virus carrying a G147R substitution in combination with an H275Y substitution in the neuraminidase protein, which confers cross-resistance to oseltamivir and peramivir, was detected from an immunocompromised inpatient in Japan, March 2016. This dual H275Y/G147R mutant virus exhibited enhanced cross-resistance to both drugs compared with the single H275Y mutant virus and reduced susceptibility to zanamivir, although it showed normal inhibition by laninamivir.

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 Source
http://dx.doi.org/10.2807/1560-7917.ES.2016.21.24.30258DOI Listing

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