The Prostate Health Index (phi) has been FDA approved for decision-making regarding prostate biopsy. Phi has additionally been shown to positively correlate with tumor volume, extraprostatic disease and higher Gleason grade tumors. Here we describe a case in which an elevated phi encouraged biopsy of a gentleman undergoing active surveillance leading to reclassification of his disease as high risk prostate cancer.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4909527PMC
http://dx.doi.org/10.1016/j.eucr.2016.04.012DOI Listing

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