Retinopathy and Uveitis Associated with Sofosbuvir Therapy for Chronic Hepatitis C Infection.

Purpose: We report a case of retinopathy and uveitis associated with sofosbuvir therapy for hepatitis C infection.

Methods: Case report.

Results: A 57-year-old-male developed ocular inflammation and retinopathy four weeks after the administration of sofosbuvir for a hepatitis C infection. Hearing loss, rheumatologic disease, and essential tremor were also noted. The ophthalmic findings resolved with discontinuation of the drug.   

Conclusion:  The authors report a case of sofosbuvir induced retinopathy and uveitis, the first associated with this emerging therapy for hepatitis C. Ophthalmologists and other treating physicians should be aware of the ophthalmic side effects of this drug.