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Precancerous Lesions of HPV-independent Vulvar Squamous Cell Carcinoma: Clinicopathologic Consideration of an Evolving Spectrum.
Adv Anat Pathol
January 2025
Department of Pathology, University of California San Diego, San Diego, CA.
Article Synopsis
- HPV-independent squamous cell carcinomas are the most common type of vulvar cancer, but their precancerous lesions are infrequently seen in clinical practice.
- Differentiated vulvar intraepithelial neoplasia (dVIN) is the main precancerous lesion associated with a high risk of progression and is often linked to lichen sclerosus, with a significant number showing TP53/p53 abnormalities.
- The review discusses various related lesions and emphasizes updates in terminology, diagnostics, biomarkers, and the underlying processes of these precancerous conditions.
A Case of Verruciform Xanthoma of Labia in a Child.
Clin Cosmet Investig Dermatol
April 2024
Dermatology Hospital of Jiangxi Province, Nanchang, Jiangxi, People's Republic of China.
Article Synopsis
- - The study presents a case of verruciform xanthoma (VX), a rare and benign skin condition, found in a 12-year-old female with vulvar lesions lasting over a decade without discomfort.
- - Examination revealed red, lobulated patches and specific histopathological features, including abnormal keratinization and inflammatory cell infiltration, leading to the diagnosis of VX.
- - Surgical treatment resulted in a successful outcome, highlighting an effective approach for managing this condition.
Diagnosis of verruciform acanthotic vulvar intra-epithelial neoplasia (vaVIN) using CK17, SOX2 and GATA3 immunohistochemistry.
Histopathology
June 2024
Department of Pathology, Brigham and Women's Hospital, Boston, MA, USA.
Article Synopsis
- Verruciform acanthotic vulvar intra-epithelial neoplasia (vaVIN) is a rare condition that does not associate with HPV and presents unique challenges in diagnosis, particularly when differentiating it from non-neoplastic lesions.
- The study evaluated the diagnostic effectiveness of three immunohistochemical markers—CK17, SOX2, and GATA3—across 16 vaVIN cases and 34 similar, non-neoplastic conditions, revealing that these markers are significantly more prevalent in vaVIN cases.
- Findings suggest that utilizing a combination of these markers can increase the sensitivity, specificity, and accuracy of vaVIN diagnosis, aiding pathologists in distinguishing it from benign hyperplastic lesions.
The Spectrum of HPV-independent Penile Intraepithelial Neoplasia: A Proposal for Subclassification.
Am J Surg Pathol
December 2023
Diagnostic and Research Institute of Pathology, Medical University Graz, Graz, Austria.
Compared with vulva, precursor lesions of human papillomavirus (HPV)-independent invasive squamous cell carcinoma (SCC) of the penis are insufficiently characterized. We analyzed the histologic and immunohistochemical characteristics of 70 peritumoral precursor lesions and correlated them with the histology and mutational profile of the adjacent HPV-negative invasive penile SCC. Atypical basal keratinocyte proliferation with variously elongated epithelial rete with premature squamatiziation, but regular superficial cornification, termed differentiated penile intraepithelial neoplasia (d-PeIN), were identified adjacent to 42/70 (60%) SCC (36/42 keratinizing ( P <0.
View Article and Find Full Text PDFVerruciform Xanthoma: Clinical and Morphologic Spectrum Across Oral, Genital, and Cutaneous Sites.
Head Neck Pathol
September 2023
Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA, USA.
Background: Verruciform xanthoma (VX) is an uncommon, benign epithelial lesion of the oral mucosa. While this entity can also present extraorally, including on the skin and in anogenital areas, the variation in its histologic features in extraoral sites is not yet well defined. Differences in the demographics and morphologic features of oral versus extraoral VX were assessed to help facilitate the accurate diagnosis and management of this lesion.
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