AI Article Synopsis
- The difluoromethyl phosphonate motif is important for creating bioactive molecules because it mimics phosphate structures in biological systems.
- Since 2010, there has been a resurgence in exploring new reactions to produce these difluoromethylated phosphonates.
- This article reviews the recent advancements in this area of research.
Article Abstract
The difluoromethyl phosphonate motif plays a crucial role in the development of bioactive molecules as it is considered as a phosphate bioisoster. Since 2010, a renewal of interest to enlarge the panel of reactions to access these difluoromethylated phosphonate-containing molecules has been witnessed. This Concept article charts the recent progress that has been made.
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| http://dx.doi.org/10.1002/chem.201601310 | DOI Listing |
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