AI Article Synopsis
- The study aimed to compare liver iron concentration (LIC) estimates obtained from R2* measurements using three different software programs, focusing on their accuracy against a standard method called FerriScan.
- A total of 15 patients' MRIs were analyzed, with particular attention to longitudinal changes in LIC through 34 serial examinations.
- Findings indicated that the Quanta Hematology program showed the closest agreement to the FerriScan estimates, and it was determined that R2* LIC values tend to be higher than R2 LIC values when iron levels are low, while the situation reverses as iron concentration increases.
Article Abstract
Purpose: In magnetic resonance imaging (MRI) relaxometry, various software programs are available to perform R2* measurements and to estimate the liver iron concentration (LIC). The main objective of our study was to compare R2* LIC values, obtained with three different software programs based on specific decay models and calibration curves, with LIC estimates provided by R2-relaxometry (FerriScan).
Methods: This retrospective study included 15 patients with 15 baseline MRIs and 34 serial examinations. R2* LIC estimates were calculated using the FuncTool, CMRtools/Thalassemia Tools and Quanta Hematology programs. Longitudinal LIC changes (ΔLIC) were calculated using the subset of 34 serial MRIs.
Results: After Bland-Altman analysis on baseline data, Quanta Hematology, which employs the monoexponential-plus-constant fit, produced the lowest mean difference [0.01 ± 0.14 log(mg/gdw)] with the closest limits of agreement. In the longitudinal setting, Quanta Hematology again gave the lowest mean difference between R2 and R2* LIC (0.1 ± 2.6 mg/gdw). Using FerriScan as reference, the value of concordant directional ΔLIC changes was the same for all programs (27/34, 85.7 %).
Conclusions: R2* LICs are higher than R2 LICs at iron levels <7 mg/gdw, while R2 LIC averages higher than R2* LIC with increasing iron load. The monoexponential-plus-constant model provided the best agreement with R2 LIC estimates.
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| http://dx.doi.org/10.1007/s11547-016-0661-2 | DOI Listing |
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