Nickel-catalyzed additions of arylboronic acids to alkynes, followed by enantioselective cyclizations of the alkenylnickel species onto tethered ketones or enones, are reported. These reactions are reliant upon the formal anti-carbonickelation of the alkyne, which is postulated to occur by the reversible E/Z isomerization of an alkenylnickel species.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4957849 | PMC |
| http://dx.doi.org/10.1021/jacs.6b04206 | DOI Listing |
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