Holter's ECG monitoring was used to investigate 140 males showing no clinical signs of coronary disease, while having 1 to 5 coronary risk factors (hypodynamia, arterial hypertension, smoking, hypercholesterolemia). Supraventricular rhythm disorders were recorded in 86%, and ventricular ones, in 69%. Transitory ST depression was detected in 15% of the cases, appearing in response to physical (90%) of mental (9%) stress or spontaneously in 1%. Ninety percent of ischemic attacks were asymptomatic. Ischemic ECG changes were nearly twice as frequent in patients with 3 to 5 coronary risk factors, as compared to those with 1 or 2 risk factors. It is therefore suggested that asymptomatic coronary disease can be suspected in some of the patients with coronary risk factors. This suspicion is confirmed by positive bicycle ergometric test in 53% of the individuals with changed Holter's ECG monitoring data. Combined use of Holter's ECG monitoring and bicycle ergometry increases twofold the detectability of electrocardiographic abnormalities.

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