AI Article Synopsis
- The study presents a unique reaction process that transforms 2-aminobenzylamines into 2-substituted benzimidazoles using oxone, occurring at room temperature with various types of aldehydes.
- The reaction starts with the condensation of 2-aminobenzylamine and aldehydes, producing a tetrahydroquinazoline intermediate.
- This intermediate then undergoes a modification through oxone treatment, resulting in the successful synthesis of the target compounds with moderate to excellent yields.
Article Abstract
An exceptional oxone mediated tandem transformation of 2-aminobenzylamines to 2-substituted benzimidazoles is reported. It occurs at room temperature with aromatic, heteroaromatic, and aliphatic aldehydes. In this reaction initial condensation of 2-aminobenzylamine with appropriate aldehydes afforded a tetrahydroquinazoline intermediate which underwent oxone-mediated ring distortion to afford the desired compounds in moderate to excellent yields.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1021/acs.orglett.6b01217 | DOI Listing |
Publication Analysis
Top Keywords
ring distortion
8
oxone mediated
8
mediated tandem
8
accessing benzimidazoles
4
benzimidazoles ring
4
distortion strategy
4
strategy oxone
4
tandem reaction
4
reaction 2-aminobenzylamines
4
2-aminobenzylamines exceptional
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!