AI Article Synopsis
- Nm23-H1 is identified as a metastasis suppressor gene whose expression is lower in patients with digestive system cancers, particularly colorectal cancer.
- A study involving 63 colorectal cancer samples found no point mutations in the nm23-H1 gene, but only 30% of the samples showed positive expression of the nm23-H1 protein.
- The findings suggest that nm23-H1 gene and protein expression are decreased in colorectal cancer compared to normal tissues, indicating that point mutations are not the main factor contributing to disease metastasis.
Article Abstract
Nm23-H1 is a metastasis suppressor gene, which is has a reduced expression in patients with digestive system cancer. However, the mechanistic basis for the genetic instability remains unknown. To study the expression of the nm23-H1 gene in patients with colorectal cancer, polymerase chain reaction-single strand conformation polymorphism was used to analyze any point mutation, and immunohistochemistry was used to detect the expression of nm23-H1. Results revealed that all 63 specimens of Chinese human colorectal cancer tissues exhibit no point mutation. Among those 63 specimens, 19 (30%) exhibited positive immunostaining for the nm23-H1 protein and 44 (70%) exhibited negative immunostaining. These observations suggested that the protein and gene expression levels of nm23-H1 are reduced in colorectal cancer compared with the adjacent normal tissues, and the point mutation in the nm23-H1 gene is not the dominant cause of metastatic colorectal cancer.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4906573 | PMC |
| http://dx.doi.org/10.3892/mco.2016.889 | DOI Listing |
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