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http://dx.doi.org/10.46582/jsrm.1102010 | DOI Listing |
Int J Pharm
January 2025
Department of Chemical Sciences, Bernal Institute, University of Limerick, Ireland; SSPC Science Foundation Ireland Research Centre for Pharmaceuticals, University of Limerick, Ireland. Electronic address:
The potent pro-inflammatory cytokine, interferon gamma (IFN-γ), is an enticing therapeutic target because of its accelerator role in several acute and chronic inflammatory processes. In this work, poloxamer 407 is developed as an in-situ gelling polymer for a long-acting formulation to deliver a serine protease, C5a peptidase (ScpA) from Streptococcus pyogenes. ScpA is well known for its activity against the complement factor C5a but has also recently been shown to cleave IFN-γ in vitro into inactive fragments.
View Article and Find Full Text PDFBiotechnol J
January 2025
Department of Marine Biotechnology & Genetic Engineering, Bangabandhu Sheikh Mujibur Rahman Maritime University, Dhaka, Bangladesh.
Due to their superior physicochemical features, chitosan thermosensitive hydrogels are multipurpose platforms that are frequently used in the biomedical industry. Many investigations have been conducted recently to modify their pore dimensions, expansion, biodegradability, stimulus-reaction characteristics, and other characteristics in order to better tailor them to the complex craniofacial tissues. They have been the focus of various studies that have attempted to load biological cargos for therapeutic and regenerative uses in the oro-facial tissues.
View Article and Find Full Text PDFiScience
January 2025
School of Mechanical Engineering, Tongji University, Shanghai 201804, China.
Thermo-responsive polymer is becoming a potential water purification and water harvesting material. To clarify the water diffusion characteristics, the desorption ratio of liquid water and water vapor for a poly (N-isopropylacrylamide) was researched by the multi-scale method. Firstly, macro and micro structures for the hydrogel with different water content were characterized.
View Article and Find Full Text PDFSci Rep
January 2025
Stomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Hangzhou, 310000, China.
Direct resin restoration has been widely used to restore the tooth defect for its convenience and minimal invasion. However, the accuracy of the final contour of class II restoration is often unpredictable and quite technique-sensitive due to the limitation of traditional matrix band system. In this study, the authors developed a novel matrix band system using shape memory polymer (SMP), which possessed two reversible shapes including digitized permanent shape to reproduce anatomical proximal contour and programmable temporary shape for clinical practice and reservation.
View Article and Find Full Text PDFMater Horiz
January 2025
School of Materials Science and Engineering, National Institute for Advanced Materials, Nankai University, Tianjin 300350, China.
Recent advances in interfacial solar steam generation have made direct solar desalination a promising approach for providing cost-effective and environmentally friendly clean water solutions. However, developing highly effective, salt-resistant solar absorbers for long-term desalination at high efficiencies and evaporation rates remains a significant challenge. We present a Janus hydrogel-based absorber featuring a surface modified with thermo-responsive hydroxypropyl cellulose (HPC) and a hydrogel matrix containing photothermal conversion units, MXene, specifically designed for long-term seawater desalination.
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