Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Population pharmacokinetics of cabotegravir following intramuscular thigh injections in adults with and without HIV.
Antimicrob Agents Chemother
December 2024
GSK, Durham, North Carolina, USA.
Article Synopsis
- - Cabotegravir, used for HIV treatment and prevention via intramuscular injection, is being evaluated for thigh muscle as an alternative injection site compared to the traditional gluteal site, with a focus on its pharmacokinetics and demographic impacts.
- - In a study involving both HIV-negative and HIV-positive participants, researchers collected and analyzed cabotegravir concentration data from thigh and gluteal injections, finding significant differences in absorption rates based on sex and body mass index (BMI).
- - The analysis indicates that while thigh injections have a slower absorption rate and slightly lower bioavailability compared to gluteal injections, the results provide important insights for optimizing dosing strategies and future research on cabotegravir use.
Treatment strategy for compartment syndrome at multiple regions due to injuries caused by a tree fall: a case report.
Int J Emerg Med
July 2024
Advanced Critical Care Center, Gifu University Hospital, 1-1 Yanagido, Gifu-Shi, Gifu, 501-1194, Japan.
Article Synopsis
- Compartment syndrome typically arises in forearm and lower leg injuries, but can also affect the gluteal and thigh muscles, requiring prompt diagnosis and treatment.
- A 76-year-old man experienced compartment syndrome in his right forearm and left lower leg after being crushed by a tree; following initial surgery, symptoms developed in his left gluteal thigh, leading to further intervention.
- The Kocher-Langenbeck surgical approach was effectively used to treat compartment syndromes in multiple regions, providing an efficient method for decompression and wound management.
Development of a population pharmacokinetic model for the novel long-acting injectable antipsychotic risperidone ISM®.
Br J Clin Pharmacol
September 2024
Laboratorios Farmacéuticos ROVI, S.A., Madrid, Spain.
Aims: The aims of this study were to develop a population pharmacokinetic (PK) model for risperidone ISM® and to investigate the relationships between active moiety exposure, as described by apparent clearance (CL), and several covariates using all data from five clinical studies.
Methods: A population PK model was developed using active moiety concentrations from a study in healthy volunteers and two studies in patients with schizophrenia. Data from a comparative bioavailability study in medically stable patients and a Phase III study in patients with acute exacerbation of schizophrenia were then incorporated, using empirical Bayesian feedback and model refinement in NONMEM.
The Gluteus Deep Investing Fascia Compartment Block: A Novel Technique for Posterior Femoral Cutaneous Nerve Block.
Local Reg Anesth
April 2024
Health Unit, International Committee of the Red Cross, Geneva, Switzerland.
Article Synopsis
- The study presents a new ultrasound-guided technique for blocking the posterior femoral cutaneous nerve (PFCN) called the "Gluteus-Deep Investing Fascia compartment Block" (GDIF block), which targets the space between the gluteus maximus muscle and deep investing fascia.
- Nineteen above-knee surgeries were performed on nine patients using the GDIF block as part of the Complete Lower Extremity Fascia Tri-compartment Block (CLEFT Block) without complications.
- Results indicate that the GDIF block effectively achieved complete PFCN blockade, allowing surgeries to proceed without the need for additional pain relief or conversion to general anesthesia.
Suspected gluteal compartment syndrome: Etiology predicts clinical course, outcomes and resource utilization.
Trauma Case Rep
June 2024
2001 Vail Ave, Department of Orthopaedic Surgery, Atrium Health Musculoskeletal Institute, Charlotte, NC 28207, USA.
Background: Gluteal Compartment Syndrome (GCS) is a rare subtype of acute compartment syndrome (ACS), complex to diagnose and potentially fatal if left untreated. The incidence of ACS is estimated to be 7.3 per 100,000 in males and 0.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!