Severity: Warning
Message: file_get_contents(https://...@pubfacts.com&api_key=b8daa3ad693db53b1410957c26c9a51b4908&a=1): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests
Filename: helpers/my_audit_helper.php
Line Number: 176
Backtrace:
File: /var/www/html/application/helpers/my_audit_helper.php
Line: 176
Function: file_get_contents
File: /var/www/html/application/helpers/my_audit_helper.php
Line: 250
Function: simplexml_load_file_from_url
File: /var/www/html/application/helpers/my_audit_helper.php
Line: 1034
Function: getPubMedXML
File: /var/www/html/application/helpers/my_audit_helper.php
Line: 3152
Function: GetPubMedArticleOutput_2016
File: /var/www/html/application/controllers/Detail.php
Line: 575
Function: pubMedSearch_Global
File: /var/www/html/application/controllers/Detail.php
Line: 489
Function: pubMedGetRelatedKeyword
File: /var/www/html/index.php
Line: 316
Function: require_once
Scope: Human taste receptor type 1 (TAS1R, T1R) gene family mediates the perception of umami and sweet tastes and regulates metabolism. This study investigated whether variants in the TAS1R are associated with food intake and susceptibility to gastric cancer (GC).
Methods And Results: A total of 1131 Koreans including 377 GC cases were analyzed to determine the dietary intake and genotype for 25 variants in TAS1R genes. Among the genotyped polymorphisms, six loci with a minor allele frequency >0.05 were tested for an association with dietary intake and GC risk. Findings suggest that TAS1R polymorphisms were associated with a variety of food intake that is beyond the known T1R-taste association. Furthermore, differential consumption for cigarettes and citrus fruits by TAS1R genetic variants may be linked to GC risk in males and females, respectively. Additionally, in males, TAS1R1 rs34160967 heterozygote showed an increased risk of GC (odds ratio: 1.52, 95% confidence interval: 1.10-2.09), independent of dietary intake. However, this GC-risk effect of TAS1R variants was not evident in females.
Conclusions: Genetic variants in TAS1R were associated with dietary consumption, which may be associated with GC risk. TAS1R1 rs34160967 may also modify the risk for GC independent of diet in Korean males.
Download full-text PDF |
Source |
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http://dx.doi.org/10.1002/mnfr.201600145 | DOI Listing |
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