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http://dx.doi.org/10.1002/rcm.7582 | DOI Listing |
Alzheimers Dement
December 2024
Department of Neurology, Mayo Clinic, Rochester, MN, USA.
Background: While disease-modifying treatments that reduce Aβ have been recently approved by the FDA, the identification of novel therapeutic targets and strategies that target underlying mechanisms to delay the AD development are still needed. Abnormal brain energy homeostasis and mitochondria dysfunction are observed early in AD. Therefore, the development of treatments to restore these defects could be beneficial.
View Article and Find Full Text PDFSci Rep
January 2025
Department of Geosciences, Princeton University, Princeton, NJ, 08540, USA.
Hypoxia tolerance and its variation with temperature, activity, and body mass, are critical ecophysiological traits through which climate impacts marine ectotherms. To date, experimental determination of these traits is limited to a small subset of modern species. We leverage the close coupling of carbon and oxygen in animal metabolism to mechanistically relate these traits to the carbon isotopes in fish otoliths (δC).
View Article and Find Full Text PDFArchaeol Anthropol Sci
December 2024
Institut Català d'Arqueologia Clàssica (ICAC-CERCA), Tarragona, ES Spain.
Unlabelled: During the Iron Age, north-eastern Iberian communities relied on crop cultivation and animal husbandry for their subsistence. The latter was mainly focused on caprine, with sheep being prominent due to their suitability to the Mediterranean climate, orography, and environment. Despite the pivotal role of sheep in livestock husbandry, information on Iberian communities' feeding strategies for this species is limited.
View Article and Find Full Text PDFSci Data
December 2024
Centre for Climate Change Research, Indian Institute of Tropical Meteorology, Ministry of Earth Sciences, Pune, India.
High-frequency precipitation (solid/liquid) isotope datasets are useful for identification of moisture sources and various dynamical and thermodynamical processes controlling precipitation formation. Here, we report three-year (2019-2021) daily rain isotope (both oxygen, δO hereafter, and hydrogen, δH, hereafter) datasets from three unique locations in India during the Indian Summer Monsoon (ISM). The locations are- (1) Port Blair- an island situated in the Bay of Bengal (BoB); (2) Mahabaleshwar, located at the crest of the Western Ghats Mountain; and (3) Tezpur, in northeast India, situated close to a dense forest.
View Article and Find Full Text PDFHuan Jing Ke Xue
January 2025
Wuhan Center, China Geological Survey (Central South China Innovation Center for Geosciences), Wuhan 430205, China.
Nitrate pollution in water bodies is a worldwide environmental problem, and identifying the sources of nitrate is of great significance to guarantee the sustainable use of water resources. A variety of water chemistry indicators and nitrate nitrogen and oxygen isotopes (N-NO and O-NO) were used to analyze the water chemistry characteristics of water bodies in Shiyan to identify the sources of nitrate in the water bodies and to calculate the contribution rate of nitrate from different pollution sources of the water bodies using the SIMMR model. The results showed that the hydrochemical types of surface water and groundwater in the study area were dominated by the HCO-Ca·Mg type, and the formation of nitrate in the water body was mainly affected by nitrification, with non-obvious denitrification.
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