Although the extraordinary agent wound is not common, the difficulties of its diagnosis, treatment, and the high medical risk as well as the indeterminacy of its prognosis bring great challenges to the clinicians. It is mainly attributed to the complexities of extraordinary agent wounds and the deficiency in the assessment technic of wound. Therefore, it is necessary and important to establish a precise assessment method to benefit the surgical planning, pre-estimation of peri-operative risk, and the doctor-patient communication. Based on the relative scientific research and our recent clinical research data, we bring forth our opinions on the current status and the development trend of the assessment of extraordinary agent wounds in this article.
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http://dx.doi.org/10.3760/cma.j.issn.1009-2587.2016.06.001 | DOI Listing |
Eur J Pharm Biopharm
January 2025
Late diagnosis is one of the major obstacles for the treatment of breast cancer which can be overcome with a system offering sensitive imaging and selective therapeutic effect. In this study, we developed a "dark-bright" multifunctional drug delivery system bringing real-time imaging and non-invasive therapy together. Theranostic ability of the system was delivered by Verteporfin (VP), serving as a fluorescence probe and a photosensitizer.
View Article and Find Full Text PDFPLoS One
January 2025
Department of Computer Science, University of Jaén, Jaén, Spain.
In the production sector, the usefulness of predictive systems as a tool for management and decision-making is well known. In the agricultural sector, a correct economic balance of the farm depends on making the right decisions. For this purpose, having information in advance on crop yields is an extraordinary help.
View Article and Find Full Text PDFProc Natl Acad Sci U S A
January 2025
College of Chemistry, State Key Laboratory of Elemento-Organic Chemistry, Key Laboratory of Functional Polymer Materials (Ministry of Education), Frontiers Science Center for New Organic Matter, Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Nankai University, Tianjin 300071, China.
On the one hand, nature utilizes hierarchical assemblies to create complex biological binding pockets, enabling ultrastrong recognition toward substrates in aqueous solutions. On the other hand, chemists have been fervently pursuing high-affinity recognition by constructing covalently well-preorganized stereoelectronic cavities. The potential of noncovalent assembly, however, for enhancing molecular recognition has long been underestimated.
View Article and Find Full Text PDFInt J Mol Sci
December 2024
Department of Pharmacy, University of Naples Federico II, 80131 Napoli, Italy.
Thrombin binding aptamer (TBA) is one of the best-known G-quadruplex (G4)-forming aptamers that efficiently binds to thrombin, resulting in anticoagulant effects. TBA also possesses promising antiproliferative properties. As with most therapeutic oligonucleotides, chemical modifications are critical for therapeutic applications, particularly to improve thermodynamic stability, resistance in biological environment, and target affinity.
View Article and Find Full Text PDFViruses
December 2024
Department of Translational Medicine, Università del Piemonte Orientale, 28100 Novara, Italy.
Hepatitis C virus (HCV) infection is a significant risk factor for liver cirrhosis and hepatocellular carcinoma (HCC). Traditionally, the primary prevention strategy for HCV-associated HCC has focused on removing infection through antiviral regimes. Currently, highly effective direct-acting antivirals (DAAs) offer extraordinary success across all patient categories, including cirrhotics.
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