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Attenuated tuberculin skin test responses associated with Mycobacterium intracellulare sputum colonization in an adolescent TB prevalence survey in Western Kenya.
Tuberculosis (Edinb)
July 2024
Kenya Medical Research Institute, Centre for Respiratory Diseases Research (CRDR), PO Box 47855-00100, Nairobi, Kenya. Electronic address:
Article Synopsis
- The study investigates how exposure to Non-tuberculous Mycobacteria (NTM) may impact BCG vaccination effectiveness and TB susceptibility, focusing on regional variations.
- Out of 5004 adolescents screened for TB, a significant portion was further analyzed, revealing TB prevalence at 0.3% and NTM prevalence at 8%, with M. intracellulare being the most common NTM species.
- Findings indicate that adolescents colonized with NTM exhibited less chronic cough and lower skin test reactivity (TST induration) compared to those not colonized, suggesting a potential role of NTM in modulating immune responses.
Characterisation and antimicrobial susceptibility pattern of non-tuberculous mycobacteria.
S Afr J Infect Dis
January 2024
Department of Medical Microbiology, Faculty of Health Sciences, University of the Free State, Bloemfontein, South Africa.
Background: Non-tuberculous mycobacteria (NTM) management comprises prolonged therapy that includes macrolides. Non-tuberculous mycobacteria can cause disease in patients with predisposing conditions such as HIV and structural lung disease. Local data on NTM disease and macrolide resistance are scarce, and routine antimicrobial susceptibility testing is currently not performed for NTM in South Africa.
View Article and Find Full Text PDFMycobacterial Infections in Invasive Turtle Species in Poland.
Pathogens
April 2023
Department of Microbiology, National Tuberculosis and Lung Diseases Research Institute, 01-138 Warsaw, Poland.
Over the last 30 years, the number of invasive turtle species living in the wild has significantly increased in Poland. This proliferation carries many threats, which mainly include the displacement of native species of animals from their natural habitats. Turtles can also be reservoirs for pathogens, including bacteria from the genus.
View Article and Find Full Text PDFand dual pulmonary infection in an immunocompetent male: first report from India.
Monaldi Arch Chest Dis
November 2022
NTEP Unit Department of Pulmonary Medicine, All India Institute of Medical Sciences, Raipur, Chhattisgarh.
A 57-year-old farmer presented with chronic cough and recurrent hemoptysis, previously treated for sputum positive pulmonary tuberculosis. Referred to us for evaluation of drug resistant tuberculosis as his sputum was persistently positive for acid fast bacilli along with radiological worsening even after 6 months of antitubercular treatment. Bronchoalveolar lavage was done and he was diagnosed with a rare mixed non-tuberculous mycobacyteria (NTM) pulmonary infection despite no immune dysfunction.
View Article and Find Full Text PDFClinical presentations of nontuberculous mycobacteria as suspected and drug-resistant tuberculosis: Experience from a tertiary care center in Eastern India.
Int J Mycobacteriol
July 2022
Department of Microbiology, All India Institute of Medical Sciences, Bhubaneswar, Odisha, India.
Background: Nontuberculous mycobacteria (NTM) are on the rise worldwide. The diagnosis and treatment of NTM disease create a dilemma for physicians as their clinical features often overlap with that of tuberculosis (TB). The present study aims to report a series of NTM infections presenting as suspected TB.
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