Biochemical selectivity profiling is an integral part of early drug development. Typically compounds from optimization phase are regularly tested for off-target activities within or across target families. This article presents workflow and critical aspects of biochemical protein kinase profiling based on microfluidic mobility shift assays.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1007/978-1-4939-3673-1_9 | DOI Listing |
Publication Analysis
Top Keywords
protein kinase
8
selectivity profiling
8
mobility shift
8
shift assays
8
kinase selectivity
4
profiling microfluid
4
microfluid mobility
4
assays biochemical
4
biochemical selectivity
4
profiling integral
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!