A case of chronic disseminated genital and perigenital warts type Buschke-Löwenstein is presented. The therapeutic problems of such cases are discussed in detail. The authors considered, that an efficient and safe treatment of the genital warts is of special importance because of the complications and psychotraumatic effect of the surgical therapy; the high relapse rate and inefficiency of local chemotherapy; the worldwide increase of such lesions induced by human papilloma virus (HPV) during the last years in connection of the induced immunosuppression; the possible link between them and some kind of invasive cancer of the penis, vulva and cervix uteri. They implicate that the systemic new therapy with immunopharmaca as the retinoids and especially the interferons or the combination of both of them, open new therapeutic ways.
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