Staphylococcus epidermidis is the main cause of bacteremia and infections of indwelling catheters, glycopeptide antibiotics are often considered as the choice of empirical drugs for the treatment of staphylococcal infections. In the present study, 12 teicoplanin nonsusceptible S. epidermidis isolates were collected between January and October 2013. All strains carried the mecA gene, displayed multiple drug resistance, and showed heterogeneous resistance to vancomycin using the population analysis profiling/area under the curve method. Multilocus sequence typing revealed four different sequence types among these isolates; eight isolates belonged to the same ST type (ST267). Pulsed-field gel electrophoresis (PFGE) with SmaI endonuclease showed four distinct pulsotypes. Six isolates that belonged to ST267 shared the same PFGE bands, indicating that they were clonally related. In addition, cell wall thickening and decreased autolysis were found in these isolates. Our study demonstrated that ST267 was the most epidemic clone among teicoplanin nonsusceptible S. epidermidis and identified a potential endemic clone in this region, which was believed to be the first report that the ST267 clone has spread in China. Our findings revealed that strengthened monitoring of S. epidermidis for drug resistance to glycopeptide antibiotics is urgently needed, and heightened measures should be taken to control the further spread of the ST267 clone.
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http://dx.doi.org/10.1089/mdr.2015.0321 | DOI Listing |
Indian J Med Res
July 2024
Department of Microbiology, Assam University, Assam, India.
Antibiotics (Basel)
June 2024
Instituto de Investigaciones en Bacteriología y Virología Molecular (IBaViM), Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Ciudad Autómoma de Buenos Aires 1113, Argentina.
The -independent oxacillin non-susceptible (MIONSA) strains represent a great clinical challenge, as they are not easily detected and can lead to treatment failure. However, the responsible molecular mechanisms are still very little understood. Here, we studied four clinical ST8-MSSA- isolates recovered during the course of antibiotic treatment from a patient suffering successive episodes of bacteremia.
View Article and Find Full Text PDFIran J Microbiol
February 2022
Department of Medical Biology, Laboratory of Microbiology and Virology, Faculty of Medicine and Pharmacy, Cadi Ayyad University, Marrakesh, Morocco.
Background And Objectives: is one of the most frequent pathogens leading to a variety of clinical manifestations. The effects of carriage on acute otitis media (AOM) are poorly studied. The study aimed to assess the serotype's distribution and antimicrobial susceptibility in children with AOM after the implementation of the pneumococcal conjugate vaccine (PCV) in Morocco.
View Article and Find Full Text PDFClin Infect Dis
October 2022
Department of Pharmacy, University of Washington School of Pharmacy, Seattle, Washington, USA.
A patient with end-stage renal disease received 2 doses of dalbavancin for methicillin-resistant Staphylococcus aureus (MRSA) arteriovenous fistula infection and presented 5 weeks later with infective endocarditis secondary to vancomycin, daptomycin, and dalbavancin nonsusceptible MRSA. Resistance was associated with walK and scrA mutations, reduced long-chain lipid content, and reduced membrane fluidity.
View Article and Find Full Text PDFJ Med Microbiol
September 2021
Division of Infectious Diseases, Department of Internal Medicine, School of Medicine, University of Patras, Patras, Greece.
Dalbavancin was approved in Europe in 2015 for skin and soft tissue infections. Data on methicillin-resistant coagulase-negative staphylococci (MR-CNS) dalbavancin susceptibility are scarce. To assess the susceptibility of MR-CNS to dalbavancin and other anti-staphylococcal agents.
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