c-JUN-N-terminal kinase (JNK) signaling is a stress-induced response that enables survival of normal cells and is also utilized by cancer cells to evade therapy. Combining JNK inhibitors with standard therapies provides a potential strategy for overcoming drug resistance. Use of the optimal combination dosing and scheduling may substantially improve outcomes for cancer patients.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4909414 | PMC |
| http://dx.doi.org/10.1080/23723556.2015.1128515 | DOI Listing |
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