Signal transducer and activator of transcription 3 (STAT3) plays a critical role in the pathogenesis of several diseases and is considered a therapeutic target in solid cancers, including lung cancer. However, we recently demonstrated a tumor suppressive function of STAT3 in kirsten rat sarcoma oncogene homolog (KRAS)-driven lung cancer. Here, we discuss these findings and their consequences.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4909454 | PMC |
| http://dx.doi.org/10.1080/23723556.2015.1036199 | DOI Listing |
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