A palladium-catalyzed decarboxylative benzylation reaction of α,α-difluoroketone enolates is reported, in which the key C(α)-C(sp(3) ) bond is generated by reductive elimination from a palladium intermediate. The transformation provides convergent access to α-benzyl-α,α-difluoroketone-based products, and should be useful for accessing biological probes.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4972046 | PMC |
| http://dx.doi.org/10.1002/anie.201604149 | DOI Listing |
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