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POST-RADIATION NEUROCOGNITIVE DEFICIT IN THE CHORNOBYL CLEAN-UP WORKERS: GERIATRIC ASPECTS (PART І).
Probl Radiac Med Radiobiol
December 2024
State Institution «National Research Center for Radiation Medicine of the National Academy of Medical Sciences of Ukraine», 53 Yuriia Illienka Str., Kyiv, 04050, Ukraine.
Objective: to study the features of cognitive disorders in the remote period following exposure to ionizing radiation (IR) in the elderly participants of the liquidation of the consequences of the Chornobyl NPP accident (Chornobyl clean-up workers) with chronic cerebrovascular disorders.
Materials And Methods: The retrospective and prospective cohort study with the external and internal controlgroups. The randomized sample of the male elderly participants (attained age more than 60 years old) in liquidationof the consequences of the accident (Chornobyl clean-up workers, liquidators) at the Chornobyl nuclear power plant(ChNPP) in 1986-1987 (main group, n = 52) recruited from the Clinico-epidemiological registry (CER) of StateInstitution «National Research Center for Radiation Medicine, Hematology and Oncology of The National Academyof Medical Sciences of Ukraine» (NRCRMHO) with verified chronic cerebrovascular disorders (CVD) was examined.
The clinico-epidemiological, diagnostic, and therapeutic aspects of methadone poisoning: a registry-based clinical study.
Ann Med Surg (Lond)
December 2024
Department of Forensic Medicine and Toxicology, Mazandaran Registry Center for Opioids Poisoning, Orthopedic Research Center, Imam Khomeini Hospital, Mazandaran University of Medical Sciences, Sari, Iran.
Objectives: Methadone is a long-acting synthetic agonist of opioid receptors, which is used as an analgesic and as an alternative treatment in opioid-dependent patients. Clinical manifestations of methadone poisoning include miotic pupils, low levels of consciousness (LOC), respiratory depression or apnea, and coma and death. Considering the high consumption of methadone in society and the prevalent instances of overdose and poisoning, whether accidental or intentional, the authors decided to investigate the clinico-epidemiological, diagnostic, and therapeutic characteristics of methadone poisoning in the Mazandaran province, northern Iran, from 2020 to 2022.
View Article and Find Full Text PDFBurden of congenital and hereditary anomalies in the population of Azad Jammu and Kashmir, Pakistan.
Pak J Med Sci
December 2024
Sajid Malik, PhD, Human Genetics Program, Department of Zoology, Faculty of Biological Sciences, Quaid-i-Azam University, 45320 Islamabad, Pakistan.
Objectives: This study was aimed to elucidate the prevalence-pattern of congenital and hereditary anomalies (CA) in the population of Azad Jammu and Kashmir (AJK), which is a logistically difficult area in the north-east of Pakistan and in the foot-hills of Himalayas.
Method: A cross-sectional clinico-epidemiological study was carried out during 2018-2020 in three districts of AJK and individuals/families with CA were recruited from hospitals, public places and through door-to-door surveys. The anomalies were classified with the help of specialized clinicians and their definitions were sought from OMIM and ICD-10 databases.
Clinico-epidemiological profiling of dengue patients in a non-endemic region of Bangladesh.
Trans R Soc Trop Med Hyg
January 2025
Department of Tropical and Infectious Disease, Tropical Disease and Health Research Center, Agamasi lane, Dhaka 1100, Bangladesh.
Background: This study aimed to characterise the clinical and epidemiological profiles of dengue patients and their outcomes during an ongoing outbreak in a non-endemic region of Bangladesh.
Methods: This prospective observational study analysed 805 confirmed dengue cases during August-December 2023. Data on demographic, clinical and laboratory profiles, as well as outcomes, were gathered using a structured questionnaire.
A Clinico-Epidemiological Study on Porokeratosis.
Indian J Dermatol
August 2024
Department of Dermatology, Mysore Medical College and Research Institute, Mysore, Karnataka, India.
Article Synopsis
- Porokeratosis (PK) is a chronic skin condition that presents as elevated, hyperkeratotic papules or plaques with a distinct raised border, linked to mutations in the mevalonate kinase enzyme.
- The study involved 11 patients, mostly females, with Mibelli's type being the most common form observed; diagnostic techniques included clinical evaluation, dermoscopy indicating a double-marginated border, and histopathological examination showing the cornoid lamella.
- Regular monitoring is essential for early detection of potential malignant changes in PK variants, emphasizing the importance of using dermoscopy for non-invasive diagnosis.
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