AI Article Synopsis
- The study aimed to evaluate vitamin D levels in children with immune thrombocytopenic purpura (ITP), revealing a high prevalence of vitamin D deficiency among both newly diagnosed and chronic cases.
- Out of 21 patients, 11 with new ITP and 7 with chronic ITP were found to have vitamin D levels below the normal range, while only 3 newly diagnosed patients had sufficient levels.
- The research suggests the potential benefit of vitamin D supplementation in ITP patients and calls for a randomized controlled trial to explore its immune-modulating effects.
Article Abstract
The primary objective of the study was to assess the vitamin D (VD) status of patients suffering from ITP. Children from the case cohort (total 21) were recruited from chronic ITP patients (followed as outpatients) and newly diagnosed ITP (prospective study) patients. VD deficiency (values <75 nmol/L) was detected in 11 patients with newly diagnosed ITP, and seven patients with chronic ITP. Only three patients with newly diagnosed, and none with chronic ITP had normal VD values. Newly diagnosed ITP patients had statistically significantly higher values (P <.044) of VD than the patients with chronic type of ITP. Platelets values did not follow VD level. VD deficiency is very common in children with either newly diagnosed or chronic ITP form. Therefore there is a utility supplementing VD in these patients. To investigate the role of VD as an immune modulating drug for patients with ITP, a prospective randomized placebo-controlled trial needs to be performed.
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| http://dx.doi.org/10.1053/j.seminhematol.2016.04.020 | DOI Listing |
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