The paper list the results of a comparative study on the clinical and haemodynamic effects of 2 medicaments, registered in the Czechoslovak Socialist Republic, i. e. dobutamine hydrochloride, Dobutrex the Federal Republic of Germany) and Dobuject (Loiras, Finland). The medicaments were applied to high-risk patients (NYHA III-IV) after open heart surgery with the low cardiac output syndrome. Dobutrex was applied in 14 patients and Dobuject in 16 patients. Both preparations improved the cardiac output shown in an increased cardiac index and left ventricular stroke work index and the pressure decrease in pulmonary capillaries measured with a wedged-in catheter. Both these preparations (Dobutrex, Dobuject) appear to have comparable parameters as regards favourable positive inotropic effects.
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BMJ Open
January 2025
Cardiovascular Sciences, University of Leicester College of Medicine Biological Sciences and Psychology, Leicester, UK.
Objectives: To explore patients' and carers' preferences for postdischarge surgical wound monitoring.
Design: Explanatory mixed methods study with an online survey followed by online interviews.
Setting: The online survey was distributed via the Cardiothoracic Interdisciplinary Research Network and cardiac surgery patient and public involvement groups in London and Leicester, UK.
Lancet
January 2025
British Heart Foundation Centre of Research Excellence, University of Edinburgh, Edinburgh, UK; Edinburgh Imaging, University of Edinburgh, Edinburgh, UK.
Background: The Scottish Computed Tomography of the Heart (SCOT-HEART) trial demonstrated that management guided by coronary CT angiography (CCTA) improved the diagnosis, management, and outcome of patients with stable chest pain. We aimed to assess whether CCTA-guided care results in sustained long-term improvements in management and outcomes.
Methods: SCOT-HEART was an open-label, multicentre, parallel group trial for which patients were recruited from 12 outpatient cardiology chest pain clinics across Scotland.
Pharmaceuticals (Basel)
January 2025
Department of Pharmaceutical Biology, Institute of Pharmaceutical and Biomedical Sciences, Johannes Gutenberg University, Staudinger Weg 5, 55128 Mainz, Germany.
The complexity of our life experiences and the rapid progress in science and technology clearly necessitate reflections from the humanities. The ever-growing intersection between science and society fosters the emergence of novel interdisciplinary fields of research. During the past decade, Medical Humanities arose to meet the need to unravel hidden information beyond technology-driven and fact-based medicine.
View Article and Find Full Text PDFBiomedicines
January 2025
Department of Orthopaedic Surgery, Hallym Sacred Heart University Hospital, Hallym University, Anyang-si 13496, Republic of Korea.
Popliteal cysts (PCs) are occasionally accompanied by knee osteoarthritis (OA) and varus malalignment. However, whether concomitant arthroscopic excision of PCs with medial open-wedge high tibial osteotomy (MOWHTO) improves the osteoarthritic environment remains unclear. Therefore, this study assessed serial changes in C-size, medial meniscus extrusion (MME), and cartilage status for up to 2 years following an MOWHTO.
View Article and Find Full Text PDFBiomedicines
January 2025
Cardiac Surgery, University of Medicine and Pharmacy "Gr. T. Popa", 700115 Iasi, Romania.
The importance of liver dysfunction in predicting mortality in patients undergoing cardiovascular surgery is an important topic due to the general desire to improve current risk scores such as EUROSCORE II (European System for Cardiac Operative Risk Evaluation), with EUROSCORE III being currently under development. The model for End-Stage Liver Disease (MELD) Score has already proven its utility in predicting outcomes for patients undergoing abdominal, cardiovascular or urological surgery. In the present study, we want to see its usefulness in proving the postoperative mortality in patients undergoing coronary artery bypass surgery.
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