AI Article Synopsis

  • Imaging with hyperpolarized [1-(13)C]pyruvate shows promise for evaluating early treatment response in cancer.
  • A study found that measurements of carbon label exchange between pyruvate and lactate were more consistent in fasted mice compared to non-fasted ones.
  • Fasted mice demonstrated higher lactate levels, suggesting that fasting improves measurement reliability and may enhance the detection of therapeutic effects.

Article Abstract

Imaging of the metabolism of hyperpolarized [1-(13) C]pyruvate has shown considerable promise in preclinical studies in oncology, particularly for the assessment of early treatment response. The repeatability of measurements of (13) C label exchange between pyruvate and lactate was determined in a murine lymphoma model in fasted and non-fasted animals. The fasted state showed lower intra-individual variability, although the [1-(13) C]lactate/[1-(13) C]pyruvate signal ratio was significantly greater in fasted than in non-fasted mice, which may be explained by the higher tumor lactate concentrations in fasted animals. These results indicate that the fasted state may be preferable for the measurement of (13) C label exchange between pyruvate and lactate, as it reduces the variability and therefore should make it easier to detect the effects of therapy. © 2016 The Authors. NMR in Biomedicine published by John Wiley & Sons Ltd.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4973679PMC
http://dx.doi.org/10.1002/nbm.3568DOI Listing

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