A correct mode of calculating liposome membrane permeability determined with dialysis is proposed. The liposome membrane permeability is calculated with regard for the ion passage through two diffusion barriers: liposomal membrane and cellophane membrane. The asymmetrical ion distribution under equilibrium conditions is shown. The asymmetry is due to the formation of unstirred layers near the membrane. The equilibrium ion concentration in unstirred layers and the measured average bulk concentration in solution are different. The formula for calculating liposome membrane permeability that takes the mentioned factors into account is suggested.
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