Interleukin 6 (IL-6)/signal transducer and activator of transcription 3 (STAT3) signaling is considered to have important oncogenic functions in prostate cancer (PCa). However, a recent study highlighted the central role of IL-6/STAT3 signaling in regulation of the ARF-MDM2-p53 senescence axis. This reversal of the postulated oncogenic properties of IL-6/STAT3 signaling in PCa has important therapeutic implications.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905394 | PMC |
| http://dx.doi.org/10.1080/23723556.2015.1090048 | DOI Listing |
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