The tumor suppressor Smad4/DPC4 is an essential transcription factor in the TGF-β pathway that was previously thought to function constitutively. We recently reported that Smad4 activity and stability are directly regulated by 2 major signaling pathways, RTK/MAPK and Wnt/GSK3. Here we examine the molecular, cellular, and potential therapeutic significance of these findings.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905428 | PMC |
| http://dx.doi.org/10.4161/23723556.2014.989133 | DOI Listing |
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