During the evolution from yeast to mammals the Mia40 protein, the regulator of the redox-sensitive mitochondrial intermembrane space import machinery, has lost its membrane-anchorage segment to become CHCHD4, which interacts with the flavoprotein apoptosis-inducing factor (AIF). Our results establish CHCHD4 as the missing link between AIF deficiency and dysfunctional biogenesis of respiratory chain complexes.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905392 | PMC |
| http://dx.doi.org/10.1080/23723556.2015.1074332 | DOI Listing |
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