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File: /var/www/html/application/controllers/Detail.php
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When the guardian becomes the enemy: Targeting ATM in PTEN-deficient cancers. | LitMetric
Ataxia telangiectasia mutated (ATM) is an important signaling molecule in the DNA damage response and inhibitors of ATM are under clinical development. We identified a synthetic lethal interaction between ATM inhibition and phosphatase and tensin homolog (PTEN) loss that was the result of increased oxidative stress. Inhibition of ATM therefore represents a novel strategy to target PTEN-associated cancers.
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