Abnormalities in maintaining the appropriate number of centrioles could be the origin of genome instability in tumor formation. Recently, we demonstrated that ectopic formation of aberrant centriole-related structures occurs even in the presence of pre-existing centrioles, leading to mitotic spindle defects and possibly contributing to tumorigenesis.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905339 | PMC |
| http://dx.doi.org/10.1080/23723556.2014.1002717 | DOI Listing |
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