The role of p53, the original "guardian of the genome", in skin has remained elusive. We have explored p53 function in human epidermal cells and demonstrated the importance of a mitosis-differentiation checkpoint to suppress potentially precancerous cells. This model places epidermal endoreplication as an antioncogenic mechanism in the face of irreparable genetic alterations.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905324 | PMC |
| http://dx.doi.org/10.1080/23723556.2014.997127 | DOI Listing |
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