We generated a mutation in the gene encoding mitogen-activated protein kinase kinase kinase 1 (Map3k1) that results in a protein with an inactive plant homeodomain (PHD). Map3k1(mPHD) cells are defective in cytokine-mediated MAPK signaling. Protein array identified transforming growth factor (TGF-β)-activated kinase 1 binding protein 1 (Tab1) as a PHD substrate. The Map3k1 PHD transfers Lys63-linked poly-ubiquitin onto Tab1 to activate MAPKs.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905292 | PMC |
| http://dx.doi.org/10.4161/23723556.2014.980659 | DOI Listing |
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