We recently reported that depletion of p62 in the background of human epidermal growth factor receptor 2 (HER2) overexpression sensitizes mammary tumor cells to amino acid deprivation, abolishes cellular transformation in vitro, and suppresses mammary tumorigenesis in vivo. Extensive investigation on the underlying molecular mechanisms has revealed a multifaceted role for p62 in HER2-associated mammary tumorigenesis.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905285 | PMC |
| http://dx.doi.org/10.4161/23723556.2014.975035 | DOI Listing |
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