PRKD2 plays an important role in tumor cell survival, proliferation, migration, and angiogenesis. We recently reported that cell death and impaired blood vessel formation evoked by inhibition of the HSP90 chaperone in human cancer cells of various tissue origins is mediated by destabilization of PRKD2.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4904966PMC
http://dx.doi.org/10.4161/23723556.2014.981444DOI Listing

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