Dysfunctions in mitophagy, the process by which mitochondria are eliminated, are associated with cancer. We found that the proautophagic protein AMBRA1 (activating molecule in beclin 1 regulated autophagy) binds the autophagosome adapter LC3, and that this interaction is crucial for mitochondrial clearance with or without involvement of the E3-ligase PARKIN. The discovery of a novel mitophagy pathway has the potential to promote new anticancer strategies.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4904902 | PMC |
| http://dx.doi.org/10.4161/23723556.2014.975647 | DOI Listing |
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