We recently unraveled a finely tuned oncogenic mechanism in which genetic and tumor microenvironment alterations act together on a crucial calcium signaling pathway. This pathway involves an interconnected equilibrium of calcium channels functioning like a binary star system in which ORAI1 homomers and ORAI1/3 heteromers are two companion stars under the influence of each other that orbit around the cancer hallmarks of apoptosis resistance and enhanced proliferation.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4904888PMC
http://dx.doi.org/10.4161/23723556.2014.975631DOI Listing

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