Transcription in the vicinity of DNA double-strand breaks (DSBs) is suppressed via a process involving ataxia telangiectasia mutated protein (ATM) and H2AK119 ubiquitylation.(1) We discuss recent findings that components of the Polybromo and Brahma-related gene 1 (BRG1)-associated factor (PBAF) remodeling complex and the polycomb repressive complex (PRC1/2) are also required.(2) Failure to activate transcriptional suppression impedes a rapid DSB repair process.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905236 | PMC |
| http://dx.doi.org/10.4161/23723548.2014.970072 | DOI Listing |
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