MYC regulates tumorigenesis by coordinating the expression of thousands of genes. We found that MYC appears to regulate the decisions between cell survival versus death and self-renewal versus senescence through the microRNA miR-17-92 cluster. Addiction to the MYC oncogene may therefore in fact be an addiction to miR-17-92.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905255 | PMC |
| http://dx.doi.org/10.4161/23723548.2014.970092 | DOI Listing |
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