Cancer stem cells (CSCs) represent a subset of tumor cells with tumor-initiating potential. We recently demonstrated that inhibition of the sumoylation pathway cleared the CSC population and repressed the outgrowth of basal breast cancer xenografts. Targeting the sumoylation pathway offers a novel treatment strategy for basal breast cancer.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905063 | PMC |
| http://dx.doi.org/10.4161/23723548.2014.964624 | DOI Listing |
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