Oxidative stress-induced sumoylation of TP53INP1 (tumor protein p53-induced nuclear protein 1) is essential to enhance the TP53 response. Sumoylation of TP53INP1 on the K113 residue, which is mediated by protein inhibitor of activated STAT 3 (PIAS3) and chromobox homolog 4 (CBX4) and removed by SUMO1/sentrin specific peptidase (SENP1, 2 and 6), favors its interaction with TP53 in the nucleus and enhances TP53-induced gene expression.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905059 | PMC |
| http://dx.doi.org/10.4161/23723548.2014.964044 | DOI Listing |
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