Objective: To evaluate the rates of retention and discontinuation of adalimumab (ADA) due to efficacy and safety in Japanese patients with rheumatoid arthritis (RA).
Methods: All patients with RA (n = 476) who were treated with ADA in the Tsurumai Biologics Communication Registry were enrolled.
Results: The retention rate of ADA was 46% at 5 years. When focusing on insufficient efficacy, previous biologics use and high baseline disease activity were significant risk factors for up to 1 year. Methotrexate (MTX) use was a significantly low risk factor after 1 year of treatment.
Conclusion: Concomitant MTX contributes to the longterm efficacy of ADA therapy.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.3899/jrheum.151006 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Capacitorless Dynamic Random Access Memory with 2D Transistors by One-Step Transfer of van der Waals Dielectrics and Electrodes.
ACS Nano
January 2025
Department of Applied Physics, The Hong Kong Polytechnic University, Kowloon, Hong Kong 999077, China.
Dynamic random access memory (DRAM) has been a cornerstone of modern computing, but it faces challenges as technology scales down, particularly due to the mismatch between reduced storage capacitance and increasing OFF current. The capacitorless 2T0C DRAM architecture is recognized for its potential to offer superior area efficiency and reduced refresh rate requirements by eliminating the traditional capacitor. The exploration of two-dimensional (2D) materials further enhances scaling possibilities, though the absence of dangling bonds complicates the deposition of high-quality dielectrics.
View Article and Find Full Text PDFBehind the Frontlines: Insights for Supporting Mental Health and Staff Retention in the Long-Term Care Workforce.
Healthcare (Basel)
December 2024
Innovation in Dementia and Aging (IDEA) Lab, University of British Columbia, Vancouver, BC V6T 1Z4, Canada.
: Canada's long-term care (LTC) sector is struggling with a significant staffing crisis related to shortages, high-turnover rate, and challenging working conditions. The COVID-19 pandemic exacerbated these issues and emphasized the need for improved mental health support for LTC staff. Understanding and addressing the wellbeing of staff is important for ensuring quality of care and promoting a positive work environment for a healthy workforce.
View Article and Find Full Text PDFIn Situ Balanced Synthesis of High-Activity Low-Spin Iron Cathode Prussian Blue for Enhanced Sodium-Ion Storage.
Nano Lett
January 2025
Key Laboratory of Advanced Structural Materials, Ministry of Education, and School of Materials Science and Engineering, Changchun University of Technology, Changchun 130012, China.
The growing market for sodium-ion batteries has stimulated interest in research on Prussian blue-type cathode materials. Iron hexacyanoferrate (FeHCF) is considered a desirable Prussian blue-type cathode, but the incomplete electrochemical property of its low-spin iron sites hinders its further practical application. In this paper, carboxymethyl cellulose is demonstrated to have an appropriate binding energy through DFT calculations, synthesize Prussian blue in situ, balance Fe and water in FeHCF, and introduce Fe vacancies to activate low-spin Fe sites.
View Article and Find Full Text PDFEnabling High-Voltage and Long Lifespan Sodium Batteries via Single-Crystal Layer-Structured Oxide Cathode Material.
ACS Nano
January 2025
Institute for Energy Electrochemistry and Urban Mines Metallurgy, School of Metallurgy, Northeastern University, Shenyang, Liaoning 110819, China.
Manganese-based layer-structured transition metal oxides are considered promising cathode materials for future sodium batteries owing to their high energy density potential and industrial feasibility. The grain-related anisotropy and electrode/electrolyte side reactions, however, constrain their energy density and cycling lifespan, particularly at high voltages. Large-sized single-crystal O3-typed Na[NiMnCuTi]O was thus designed and successfully synthesized toward high-voltage and long-lifespan sodium batteries.
View Article and Find Full Text PDFCommercial SiO Encapsulated in Hybrid Bilayer Conductive Skeleton as Stable Anode Coupling Chemical Prelithiation for Lithium-Ion Batteries.
Small
January 2025
Guangxi Key Laboratory of Petrochemical Resource Processing and Process Intensification Technology, School of Chemistry and Chemical Engineering, Guangxi University, Nanning, 530004, P. R. China.
Although Silicon monoxide (SiO) is regarded as the most promising next-generation anode material, the large volume expansion, poor conductivity, and low initial Coulombic efficiency (ICE) severely hamper its commercialization application. Designing a multilayer conductive skeleton combined with advanced prelithiation technology is considered an effective approach to address these problems. Herein, a reliable strategy is proposed that utilizes MXene and carbon nanotube (CNT) as dual-conductive skeletons to encapsulate SiO through simple electrostatic interaction for high-performance anodes in LIBs, while also performing chemical prelithiation.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!