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Peptide sequences from the first Castoroides ohioensis skull and the utility of old museum collections for palaeoproteomics. | LitMetric

AI Article Synopsis

  • Vertebrate fossils have been housed in museums for centuries, which offer opportunities to discover preserved proteins in these ancient remains.
  • This research focuses on the nasal turbinates of the first discovered skull of Castoroides ohioensis, dating back to 1845, making it the oldest specimen analyzed using palaeoproteomic methods.
  • The study successfully identified collagen I peptides and a beta haemoglobin peptide, confirming C. ohioensis's classification within the Rodentia group and highlighting the value of museum specimens for protein recovery and evolutionary studies.

Article Abstract

Vertebrate fossils have been collected for hundreds of years and are stored in museum collections around the world. These remains provide a readily available resource to search for preserved proteins; however, the vast majority of palaeoproteomic studies have focused on relatively recently collected bones with a well-known handling history. Here, we characterize proteins from the nasal turbinates of the first Castoroides ohioensis skull ever discovered. Collected in 1845, this is the oldest museum-curated specimen characterized using palaeoproteomic tools. Our mass spectrometry analysis detected many collagen I peptides, a peptide from haemoglobin beta, and in vivo and diagenetic post-translational modifications. Additionally, the identified collagen I sequences provide enough resolution to place C. ohioensis within Rodentia. This study illustrates the utility of archived museum specimens for both the recovery of preserved proteins and phylogenetic analyses.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4920319PMC
http://dx.doi.org/10.1098/rspb.2016.0593DOI Listing

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