A new hybrid material based on sulforhodamine B dye-loaded silica mesoporous nanoparticles capped with a self-immolative gate has been synthesized and characterized. The gated material's controlled release behavior is monitored under different pH conditions. Under acidic and neutral conditions, a low level of dye release is detected. However, at slightly basic pH, significant dye release occurs owing to deprotonation of the phenol moiety in the capping molecule, which results in its disassembly.
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http://dx.doi.org/10.1002/chem.201602126 | DOI Listing |
J Pharm Sci
January 2025
Nanotech Laboratory, Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research (NIPER) Guwahati, Changsari, Kamrup 781101, Assam, India. Electronic address:
The application of mesoporous silica nanoparticles (MSN) as a drug carrier system got immense attention in the past few years due to their exceptional high drug loading efficiency. However, the process of drug loading is quite challenging compared to other lipid-based drug delivery systems. Hence, the MSNs using different catalysts were synthesized, and their mesoporous material characteristic was confirmed by the type IV adsorption-desorption isotherm using BET analyzer.
View Article and Find Full Text PDFACS Appl Mater Interfaces
January 2025
Centre for Advanced Laser Manufacturing (CALM), School of Mechanical Engineering, Shandong University of Technology, Zibo 255000, P. R. China.
Developing versatile, scalable, and durable coatings that repel various matters in different service environments is of great importance for engineered materials applications but remains highly challenging. Here, the mesoporous silica microspheres (HMS) fabricated by the hard template method were utilized as micro-nanocontainers to encapsulate the hydrophobic agent of perfluorooctyltriethoxysilane (F13) and the corrosion inhibitor of benzotriazole (BTA), forming the functional microsphere of F-HMS(BTA). Moreover, the synthesized organosilane-modified silica sol adhesive (SMP) and F-HMS(BTA) were further employed as the binder and functional filler to construct a superhydrophobic self-healing coating of SMP@F-HMS(BTA) on various engineering metals through scalable spraying.
View Article and Find Full Text PDFAdv Sci (Weinh)
January 2025
State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Chemistry and Chemical Engineering, Donghua University, Shanghai, 201620, China.
The combination of photosensitizers (PSs) and nanomaterials is a widely used strategy to enhance PS efficacy and broaden their applicability. However, the current nanocarrier-based delivery strategies focus on conventional PSs, neglecting the critical issue of PS phototoxicity. In this study, DHUOCl-25, an activatable PS (aPS) activated by hypochlorous acid, is synthesized by combining a silicon source structure and an activation unit.
View Article and Find Full Text PDFNanotechnol Sci Appl
January 2025
Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Universitas Padjadjaran, Sumedang, 45363, Indonesia.
Purpose: Improving drug solubility is crucial in formulating poorly water-soluble drugs, especially for oral administration. The incorporation of drugs into mesoporous silica nanoparticles (MSN) is widely used in the pharmaceutical industry to improve physical stability and solubility. Therefore, this study aimed to elucidate the mechanism of poorly water-soluble drugs within MSN, as well as evaluate the impact on the dissolution and physical stability.
View Article and Find Full Text PDFACS Med Chem Lett
January 2025
Key Laboratory of Biomedical Functional Materials, School of Science, China Pharmaceutical University, Nanjing 211198, China.
In this study, hollow mesoporous silica nanoparticles (HMSN) coated with a 4T1 tumor cell membrane were used to construct biomimetic nanomaterials (DTX@CHMSN) for the treatment of breast cancer. The nanodrug can improve the water solubility of polyenetaxel (DTX) by taking advantage of the special structure, good biocompatibility, and adjustable surface chemical properties of HMSN. Hollow mesoporous silica nanoparticles are coated with 4T1 cell membranes derived from homologous tumors (CHMSN).
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